A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure.
نویسندگان
چکیده
منابع مشابه
The human gene AHNAK encodes a large phosphoprotein located primarily in the nucleus
AHNAK is a newly identified human gene notable for the exceptional size (c.a. 700 kD) and structure of its product, and for the repression of its expression in human neuroblastoma cells. Here we report the identification and partial characterization of the protein encoded by AHNAK. The protein is located principally (but not exclusively) in the nucleus and is phosphorylated on both serine and t...
متن کاملStructure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein.
We have characterized a growth factor-inducible gene, fisp-12, previously isolated by differential screening of a lambda complementary DNA library of RNA from serum-stimulated NIH 3T3 cells, and have shown that it encodes a cysteine-rich secreted protein of 348 amino acids. The induction of fisp-12 mRNA is rapid and remains for at least 8 h at a high level of expression. The increased level of ...
متن کاملDesmoyokin, a 680 kDa keratinocyte plasma membrane-associated protein, is homologous to the protein encoded by human gene AHNAK.
We have obtained a monoclonal antibody (33A-3D) that specifically recognize desmoyokin, a 680 kDa desmosomal plaque protein that is well characterized in bovine muzzle epidermis. A cDNA clone (DY6, 3693 bp) was isolated by immunoscreening a mouse keratinocyte expression library with 33A-3D, and it was confirmed that DY6 has a partial coding sequence for desmoyokin. DY6 consists of highly homolo...
متن کامل( NH 3 ) 4 ] , a Structure with an Unexpected Rod Packing
rra/w-[Ru(S03H)2(N H ,)4], monoclinic, space group P2 Jn, Z =2, a 619.4(3), b = 701.8(3), c = 1068.6(6) pm, ß = 96.32(3)°. In the centrosymmetric octahedral complex the two inde pendent R u -N bonds are equal within experimental error (average R u -N 214.0 pm). The rather short R u -S bonds (227.6 pm) indicate a very weak rrarcs-influence o f the S 0 3H li gand. Caused by the protonation, one...
متن کاملOnconase: an unusually stable protein.
Several members of the RNase A superfamily are endowed with antitumor activity, showing selective cytotoxicity toward tumor cell lines. One of these is onconase, the smallest member of the superfamily, which at present is undergoing phase-III clinical trials as an antitumor drug. Our investigation focused on other interesting features of the enzyme, such as its unusually high denaturation tempe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.12.5472